Manuela Cervelli Selected Research

Polyamine Oxidase

1/2022	Transgenic Mouse Overexpressing Spermine Oxidase in Cerebrocortical Neurons: Astrocyte Dysfunction and Susceptibility to Epileptic Seizures.
2/2020	Epileptic seizures and oxidative stress in a mouse model over-expressing spermine oxidase.
11/2019	Link between spermine oxidase and apoptosis antagonizing transcription factor: A new pathway in neuroblastoma.
9/2018	Glutamate Excitotoxicity Linked to Spermine Oxidase Overexpression.
1/2017	Adaptive responses of heart and skeletal muscle to spermine oxidase overexpression: Evaluation of a new transgenic mouse model.
3/2016	Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse.
1/2016	HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine Oxidase Activation in Human Neuroblastoma Cells.
3/2014	Spermine metabolism and radiation-derived reactive oxygen species for future therapeutic implications in cancer: an additive or adaptive response.
10/2010	Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm.

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Manuela Cervelli Research Topics

Disease

11	Neoplasms (Cancer) 01/2022 - 04/2011
4	Neuroblastoma 11/2019 - 02/2004
3	Blister (Bulla) 01/2022 - 11/2020
3	Seizures (Absence Seizure) 01/2022 - 03/2016
3	Gliosis 01/2022 - 03/2016
3	Epilepsy (Aura) 01/2022 - 01/2020
3	Muscular Atrophy (Muscle Atrophy) 11/2020 - 01/2017
2	Atrophy 11/2020 - 02/2018
2	Brain Diseases (Brain Disorder) 02/2020 - 01/2020
2	Brain Injuries (Brain Injury) 03/2016 - 01/2013
2	Breast Neoplasms (Breast Cancer) 11/2014 - 10/2010
1	Hemorrhage 11/2021
1	Neuroinflammatory Diseases 01/2021
1	Mental Disorders (Mental Disorder) 01/2020
1	Infections 11/2018
1	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2018
1	Hypertrophy 02/2018
1	Inflammation (Inflammations) 03/2014
1	Hyperthermia 03/2014
1	Carcinogenesis 03/2014

Drug/Important Bio-Agent (IBA)

11	PolyaminesIBA 01/2021 - 10/2010
9	Polyamine OxidaseIBA 01/2022 - 10/2010
4	1,2-cyclohexanediamine (dach)IBA 01/2022 - 03/2016
4	SpermineIBA 01/2022 - 10/2010
3	Cantharidin (Cantharides)IBA 01/2022 - 11/2020
3	Kainic Acid (Kainate)IBA 02/2020 - 01/2013
3	Pharmaceutical PreparationsIBA 01/2017 - 02/2012
3	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2016 - 09/2013
3	EnzymesIBA 05/2015 - 02/2004
2	Ion Channels (Ion Channel)IBA 01/2022 - 01/2020
2	Ionotropic Glutamate ReceptorsIBA 01/2022 - 01/2020
2	Terpenes (Terpenoids)IBA 11/2021 - 11/2020
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 02/2020 - 05/2015
2	Transcription Factors (Transcription Factor)IBA 11/2019 - 11/2014
2	Proteins (Proteins, Gene)FDA Link 11/2018 - 02/2004
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2022
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2022
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2022
1	RNA (Ribonucleic Acid)IBA 11/2020
1	Dexamethasone (Maxidex)FDA LinkGeneric 11/2020
1	SpermidineIBA 02/2018
1	Glutamic Acid (Glutamate)FDA Link 03/2016
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2016
1	Estrogen ReceptorsIBA 11/2014
1	A-Form DNA (A-DNA)IBA 03/2014
1	Oxidoreductases (Dehydrogenase)IBA 09/2013
1	AminesIBA 09/2013
1	N(1),N(11)-diethylnorspermineIBA 10/2010
1	N(1)- ethyl- N- (11)- ((cyclopropyl)methyl)- 4,8- diazaundecane- 1,11- diamineIBA 10/2010

Therapy/Procedure

4	Therapeutics 05/2015 - 09/2013